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Natural compounds and their biological activity I. Antioxidant activity of selected potentially toxic herbal drugs
Římanová, Elena ; Opletal, Lubomír (advisor) ; Siatka, Tomáš (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Mgr. Elena Římanová Consultant: Doc. RNDr. Lubomír Opletal, CSc. Title of Thesis: Natural compounds and their biological activity I. Antioxidative activity of selected potentially toxic herbal drugs. 14 dried samples of morphological parts of potentially toxic plants, or plants with other type of restriction for common use, eventually obsolete plants (comfrey root, calamus root black locust flower, peony flower, red weed poppy flower, leaf of hawthorn with flowers, coldsfood leaf, mistletoe herb, melilot herb, woodfuff herb, pulmonaria herb, motherwort herb, St. John's wort herb, hawthorn fruit), were chosen for the evaluation of their antioxidant activity. These samples were collected from 3 regions of medicinal herbs purchases (Nepomuk, Slatiňany, Strážnice). The standardised extracts from these morphological parts were tested for their antioxidant activity (DPPH assay, EC50 values), and total phenolics were measured (Folin-Ciocalteau reagent, GAE/mg of extract). Relatively significant correlation was determined between total phenolics content and antioxidant activity by regression analysis (R2 =0,7825). Most of the samples, used for analysis, and practically no matter...
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